GE医疗近日宣布推出AxiChrom™新一代低压层析柱产品。所有的层析柱系列产品都能够实现对柱操作和维护的精益模式。通过智能装柱、直观操作和规模的可预测放大，AxiChrom确保层析分离过程更简便、更安全以及更有效率。层析柱产品采用了柱管的创新性设计，并能够提供便捷的设备维护。层析柱的直径范围规模从50 MM到1000 MM, 便于客户在纯化技术开发到大规模生产过程中选择适合自己特定规模尺寸的层析柱用于层析分离。
智能装柱能够为BioProcess™介质提供经过预设和验证的填充方法，节约时间并降低了对操作者的人为依赖性和装柱在整个流程中的重要性。它还能够获得准确而高重复性的装柱效果，同时降低对专业人员的需求，更快协调不同产品线的转换。
层析柱新品可通过AxiChrom Master 和 UNICORN™ 指导模板以互动的方式指导用户操作和提供服务。这种直观的操控模式有助于降低操作故障率，同时节省时间。填充AxiChrom 400或更高型号的层析柱都可以通过AxiChrom Master互动用户界面来指导操作以及进行有效控制，这种界面是一个独立设备，包括了一个触摸屏操作界面，可指导用户按步骤操作和方便检查充装、卸柱和维护中的重要环节。
AxiChrom层析柱还特别提供了预升级功能，确保了应用于各种柱直径和长度中的可重复利用性，易于升级的同时能够保证产品在不同制造地点生产的一致性。全方位的支持和规范指导保障了快速和快捷的安装和技术转化。新型的层析柱产品易于操作和维护，即使更大型号的柱体也可由一个操作人员完成。
“ 新一代AxiChrom层析柱的推出在帮助用户提高产量、缩短安装、填充和维护时间方面迈出了突破性的一步，同时极大提高了层析柱整体表现的全面一致性。” GE医疗集团生命科学部总裁兼首席执行官Peter Ehrenheim 表示，“创新性的设计理念可以帮助我们的客户降低产品生产周期以及应对生产过程中各种变化的影响。”
“AxiChrom 是公司众多创新技术中的一个部分, 秉承了精益制造和追求卓越的理念，不断推动下游纯化领域在简约化、高效性和经济性方面步入一个新的里程； 它的显著特征包括能够有效缩短产品上市时间，提高产量和减少成本。这些创新产品包括：不同特性的Bioprocess层析介质；从中试到大规模生产的AxiChrom低压层析柱；成熟的ReadyToProcess™ 解决方案平台适用于从细胞培养到纯化的整个生物工程领域；PreDictor™ 96 孔滤化板能够实现高通量的工艺的开发。
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The AxiChrom column platform is a revolutionary concept in column chromatography that simplifies column handling at all scales from process development to full-scale production. AxiChrom columns (Fig 1) introduce three key features – Intelligent Packing, Intuitive handling, and Predictable scale-up – that together make process chromatography easier, safer, and more efficient.
Intelligent Packing: Verified, preprogrammed, axial compression packing methods save time and ensure accurate and reproducible packing results. This built-in experience reduces operator-dependence and facilitates faster product change-over.
Intuitive handling: Columns are simple to operate and service. Pivot or swing-out column tubes are safer and easier to handle. AxiChrom Master and UNICORN™ wizards guide users through key process steps to save time in method creation, set-up and maintenance.
Predictable scale-up: Straightforward scale-up and techtransfer due to a liquid distribution system designed using the same analytical and computational fluid dynamic (CFD) modeling tools. Sanitizable columns support cleaning validation. Full technical and regulatory support promote fast, trouble-free start-up. The entire AxiChrom column line, from 50 to 1000 mm, has been verified to give superior performance with newgeneration, high-flow Capto™ and MabSelect™ media families as well as with other BioProcess™ Media.
AxiChrom columns - Simple operation & Superior performance
The AxiChrom™ column platform is a revolutionary concept that simplifies column handling at all scales from process development to full-scale production. Developed from a long history of experience in column packing, the AxiChrom platform displays superior performance.
Through its three key features - Intelligent Packing, intuitive handling, and predictable scale-up - AxiChrom columns introduce leanenabling practices that make process chromatography easier, safer, and more efficient.
Includes technical specifications and 12 frequently asked questions.
